{"id":5926,"date":"2022-02-22T08:28:02","date_gmt":"2022-02-22T08:28:02","guid":{"rendered":"https:\/\/medicinasinc.com\/sk\/?post_type=product&p=5926"},"modified":"2022-03-22T00:45:23","modified_gmt":"2022-03-22T00:45:23","slug":"buy-thj-018","status":"publish","type":"product","link":"https:\/\/medicinasinc.com\/sk\/product\/buy-thj-018\/","title":{"rendered":"K\u00fapi\u0165 THJ-018"},"content":{"rendered":"

Napriek rast\u00facej prevalencii nov\u00fdch psychoakt\u00edvnych zl\u00fa\u010den\u00edn v s\u00fa\u010dasnosti nie s\u00fa k dispoz\u00edcii \u017eiadne \u00fadaje o \u013eudskom metabolizme, \u010do s\u0165a\u017euje laborat\u00f3rnu dokument\u00e1ciu prij\u00edmania vzoriek mo\u010du a hodnotenie farmakodynamick\u00fdch, farmakokinetick\u00fdch a toxikologick\u00fdch vlastnost\u00ed liekov.<\/p>\n

Syntetick\u00e9 anal\u00f3gy konope indazolu JWH-018 a THJ-2201 boli uveden\u00e9 na trh v roku 2014 ako THJ-018 a THJ-2201.<\/p>\n

THJ 018 je \u00faplne nov\u00fd syntetick\u00fd liek, ktor\u00fd je mo\u017en\u00e9 zak\u00fapi\u0165. Je klasifikovan\u00fd ako kanabinoid. T\u00e1to zl\u00fa\u010denina je deriv\u00e1tom dobre zn\u00e1meho lieku jwh 018.<\/p>\n

N\u00e1rodn\u00fd s\u00fadny laborat\u00f3rny informa\u010dn\u00fd syst\u00e9m m\u00e1 pod\u013ea AM-2201 220 spr\u00e1v THJ-2201. V janu\u00e1ri 2015 Drug Enforcement Administration zaradil THJ-2201 do zoznamu I kv\u00f4li mnoh\u00fdm nepriazniv\u00fdm udalostiam.<\/p>\n

MET\u00d3DY: Po inkub\u00e1cii 10 mol\/L THJ-018 a THJ-2201 v \u013eudsk\u00fdch hepatocytoch po\u010das 3 hod\u00edn, na objavenie optim\u00e1lnych metabolitov\u00fdch markerov sme pou\u017eili hmotnostn\u00fa spektrometriu s vysok\u00fdm rozl\u00ed\u0161en\u00edm (HR-MS) (TripleTOF 5600+). Skenovanie produktov\u00fdch i\u00f3nov s filtrami s hromadn\u00fdmi defektmi sa aktivovalo \u00fapln\u00fdm skenovan\u00edm a z\u00edskavan\u00edm z\u00e1vislou od inform\u00e1ci\u00ed. MetaSite sa pou\u017eil na predpovede metabolitov in silico, ktor\u00e9 sa potom porovnali s metabolitmi n\u00e1jden\u00fdmi v \u013eudsk\u00fdch hepatocytoch.<\/p>\n

V\u00ddSLEDKY: Na\u0161lo sa 13 metabolitov THJ-018 s hydroxyl\u00e1ciou na N-pentylovom re\u0165azci a n\u00e1slednou oxid\u00e1ciou resp. glukuronid\u00e1cia je prevl\u00e1daj\u00facimi metabolick\u00fdmi cestami. V THJ-2201 sa na\u0161lo 27 metabolitov, pri\u010dom v\u00e4\u010d\u0161ina bola oxida\u010dn\u00e1 defluorin\u00e1cia, po ktorej nasledovala karboxyl\u00e1cia alebo glukuronid\u00e1cia, ako aj glukuronid\u00e1cia hydroxylovan\u00fdch metabolitov.<\/p>\n

Obe zl\u00fa\u010deniny vykazovali synt\u00e9zu dihydrodiolu na naftal\u00e9novej skupine. Predikcia MetaSite bola presn\u00e1 pre metabolity hepatocytov THJ-018, zatia\u013e \u010do oxida\u010dn\u00e1 defluorin\u00e1cia THJ-2201 bola podhodnoten\u00e1.<\/p>\n

Z\u00c1VERY: Sk\u00famali sme metabolizmus THJ-018 a THJ-2201 v \u013eudsk\u00fdch hepatocytoch pomocou HR-MS na z\u00edskavanie \u00fadajov a spracovanie a laborat\u00f3ri\u00e1m odpor\u00fa\u010dame pr\u00edslu\u0161n\u00e9 indik\u00e1tory na identifik\u00e1ciu po\u017eitia THJ-018 a THJ-2201 a prirovnanie zdokumentovan\u00fdch nepriazniv\u00fdch v\u00fdsledkov k t\u00fdmto nov\u00fdm syntetick\u00fdm kanabinoidom.<\/p>\n

SC sa via\u017eu na endog\u00e9nne kanabinoidn\u00e9 receptory a vytv\u00e1raj\u00fa kanabimimetick\u00e9 \u00fa\u010dinky porovnate\u013en\u00e9 s 9 -tetrahydrokanabinol (1, 2). Zneu\u017e\u00edvanie SC3 vedie k z\u00e1va\u017en\u00fdm ved\u013eaj\u0161\u00edm \u00fa\u010dinkom, ako je ak\u00fatne po\u0161kodenie obli\u010diek, infarkt myokardu a smr\u0165 (3, 4).<\/p>\n

Napriek t\u00fdmto rizik\u00e1m \u013eudia na\u010falej konzumuj\u00fa SC. Mnoho SC bolo napl\u00e1novan\u00fdch v Spojen\u00fdch \u0161t\u00e1toch, Japonsku a v\u00e4\u010d\u0161ine eur\u00f3pskych kraj\u00edn (napr\u00edklad JWH018, JWH-073, AKB48 a XLR-11); neust\u00e1le sa v\u0161ak objavuj\u00fa \u010fal\u0161ie \u0161trukt\u00farne r\u00f4znorod\u00e9 zl\u00fa\u010deniny.<\/p>\n","protected":false},"excerpt":{"rendered":"

K\u00fapte si THJ-018 (SGT-17) na predaj v Eur\u00f3pe, Ve\u013ekej Brit\u00e1nii je syntetick\u00fd kanabinoid, ktor\u00fd je indazolov\u00fdm anal\u00f3gom JWH-018 a pred\u00e1va sa online ako dizajnov\u00fd liek. K dispoz\u00edcii je ve\u013ekoobchodn\u00e1 objedn\u00e1vka<\/p>\n","protected":false},"featured_media":5940,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[2596],"product_tag":[4104,4103,4109,4106,4107,4105,4108],"class_list":{"0":"post-5926","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-kanabinoidy-na-predaj","7":"product_tag-ako-kpi-thj-018-online","8":"product_tag-buy-thj-018-online","9":"product_tag-kde-kpi-thj-018-online","10":"product_tag-nkup-thj-018-online","11":"product_tag-najlepie-miesto-na-kpi-thj-018-online","12":"product_tag-objednvka-thj-018-online","13":"product_tag-thj-018-na-predaj","15":"first","16":"instock","17":"shipping-taxable","18":"purchasable","19":"product-type-variable"},"yoast_head":"\nK\u00fapi\u0165 THJ-018 - SGT-17 - Najlep\u0161ie najlep\u0161ie glob\u00e1lne lieky<\/title>\n<meta name=\"description\" content=\"K\u00fapi\u0165 THJ-018 (SGT-17) na predaj Eur\u00f3pa, Spojen\u00e9 kr\u00e1\u013eovstvo je syntetick\u00fd kanabinoid, ktor\u00fd je indazolov\u00fdm anal\u00f3gom JWH-018 a pred\u00e1va sa online ako dizajnov\u00fd liek. 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