{"id":5902,"date":"2022-02-22T08:09:55","date_gmt":"2022-02-22T08:09:55","guid":{"rendered":"https:\/\/medicinasinc.com\/sk\/?post_type=product&p=5902"},"modified":"2022-03-22T00:46:16","modified_gmt":"2022-03-22T00:46:16","slug":"buy-5f-adb","status":"publish","type":"product","link":"https:\/\/medicinasinc.com\/sk\/product\/buy-5f-adb\/","title":{"rendered":"K\u00fapte si 5F-ADB"},"content":{"rendered":"

5F-ADB (alternat\u00edvne hl\u00e1skovan\u00e9 5F-MDMB-PINACA) je syntetick\u00fd kanabinoid odvoden\u00fd z indazolu, ktor\u00fd sa pou\u017e\u00edva ako akt\u00edvna zlo\u017eka v syntetick\u00fdch kanabisov\u00fdch produktoch a pred\u00e1va sa online ako dizajnov\u00e1 droga.<\/p>\n

5F -ADB je siln\u00fd agonista receptora CB1, aj ke\u010f jeho selektivita pre tento receptor nie je zn\u00e1ma. 5F-ADB bol prv\u00fdkr\u00e1t n\u00e1jden\u00fd v novembri 2014 pomocou posmrtn\u00fdch vzoriek z\u00edskan\u00fdch od osoby, ktor\u00e1 zomrela po u\u017eit\u00ed produktu obsahuj\u00faceho t\u00fato drogu. N\u00e1sledn\u00e9 testovanie odhalilo, \u017ee 5F-ADB bol zisten\u00fd celkovo u desiatich \u013eud\u00ed, ktor\u00ed zomreli v Japonsku medzi septembrom a decembrom 2014 na nevysvetlite\u013en\u00e9 pred\u00e1vkovanie drogami. Na z\u00e1klade relat\u00edvne n\u00edzkych hlad\u00edn objaven\u00fdch v tkanivov\u00fdch testoch sa predpoklad\u00e1, \u017ee 5F-ADB je mimoriadne siln\u00fd a zd\u00e1 sa, \u017ee je podstatne nebezpe\u010dnej\u0161\u00ed ako predt\u00fdm pred\u00e1van\u00e9 syntetick\u00e9 kanabisov\u00e9 lieky.<\/p>\n

N-[[1-(5- flu\u00f3rpentyl)-1H-indazol-3-yl]karbonyl]<\/p>\n

-3-metyl-D-val\u00edn metylester (5F-ADB) je vysoko siln\u00e9 syntetick\u00e9 kanabis, ktor\u00fd u \u013eud\u00ed ob\u010das sp\u00f4sobuje v\u00e1\u017ene psychotick\u00e9 sympt\u00f3my fat\u00e1lne.<\/p>\n

Aby sme objasnili neur\u00f3nov\u00e9 mechanizmy za 5F-toxicitou, ADB sme \u0161tudovali jeho \u00fa\u010dinky na dopaminergn\u00e9 a serotonergn\u00e9 okruhy stredn\u00e9ho mozgu, ktor\u00e9 reguluj\u00fa r\u00f4zne z\u00e1kladn\u00e9 funkcie mozgu, vr\u00e1tane t\u00fdch, ktor\u00e9 s\u00fa spojen\u00e9 so spr\u00e1van\u00edm s\u00favisiacim s odme\u0148ovan\u00edm. Elektrofyziologick\u00e9 techniky ex vivo sa pou\u017eili na zaznamenanie zmien v spont\u00e1nnej aktiva\u010dnej aktivite dopaminergn\u00fdch a serotonergn\u00fdch neur\u00f3nov produkovan\u00fdch 5F-ADB.<\/p>\n

5F-ADB (1 M) dramaticky zv\u00fd\u0161ilo r\u00fdchlos\u0165 spont\u00e1nneho odp\u00e1lenia dopam\u00ednergn\u00fdch neur\u00f3nov, ale nedok\u00e1zali ich aktivova\u0165 v pr\u00edtomnosti antagonistu CB1 AM251 (1 M). Rovnak\u00e1 koncentr\u00e1cia 5F-ADB na druhej strane nemala \u017eiadny vplyv na aktivitu serotonergn\u00fdch neur\u00f3nov. Tieto zistenia ukazuj\u00fa, \u017ee 5F-ADB aktivuje lok\u00e1lne receptory CB1 a posil\u0148uje dopaminergn\u00e9 syst\u00e9my v strednom mozgu, pri\u010dom nem\u00e1 \u017eiadny vplyv na serotonergn\u00e9 syst\u00e9my v strednom mozgu.<\/p>\n","protected":false},"excerpt":{"rendered":"

K\u00fapi\u0165 5F-ADB na predaj Ve\u013ek\u00e1 Brit\u00e1nia, Eur\u00f3pa, \u010c\u00edna (tie\u017e zn\u00e1my ako 5F-MDMB-PINACA) je syntetick\u00fd kanabinoid na b\u00e1ze indazolu z rodiny indazol-3-karboxamidov, k dispoz\u00edcii je ve\u013ekoobchodn\u00e1 objedn\u00e1vka<\/p>\n","protected":false},"featured_media":5933,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[2596],"product_tag":[4066,4068,4069,4072,4070,4071,4076,4074,4073,4067,4075],"class_list":{"0":"post-5902","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-kanabinoidy-na-predaj","7":"product_tag-5f-adb","8":"product_tag-5f-adb-prok","9":"product_tag-5f-mdmb-pinaca","10":"product_tag-ako-na-kpi-5f-adb-online","11":"product_tag-buy-5f-adb-online","12":"product_tag-c20h28fn3o3","13":"product_tag-kde-kpi-5f-adb-online","14":"product_tag-najlepie-miesto-na-nkup-5f-adb-online","15":"product_tag-objednvka-5f-adb-online","16":"product_tag-5f-adb-na-predaj","17":"product_tag-v1715016-75-3","19":"first","20":"instock","21":"featured","22":"shipping-taxable","23":"purchasable","24":"product-type-variable"},"yoast_head":"\nK\u00fapi\u0165 5F-ADB - 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