{"id":5310,"date":"2022-02-21T18:38:01","date_gmt":"2022-02-21T18:38:01","guid":{"rendered":"https:\/\/medicinasinc.com\/sk\/?post_type=product&p=5310"},"modified":"2022-03-22T01:02:32","modified_gmt":"2022-03-22T01:02:32","slug":"kupit-roxikodon-30-mg","status":"publish","type":"product","link":"https:\/\/medicinasinc.com\/sk\/product\/kupit-roxikodon-30-mg\/","title":{"rendered":"K\u00fapi\u0165 Roxicodone 30 mg"},"content":{"rendered":"

Online n\u00e1kup tabliet Roxicodone 30 mg<\/p>\n

Tablety ROXICODONE (oxykod\u00f3n HCl) s\u00fa ur\u010den\u00e9 na lie\u010dbu stredne silnej a\u017e silnej bolesti, ktor\u00e1 si vy\u017eaduje opioidn\u00e9 analgetikum a pri ktorej s\u00fa neopioidn\u00e9 alternat\u00edvy ne\u00fa\u010dinn\u00e9.<\/p>\n

Obmedzenia pou\u017e\u00edvania<\/p>\n

Vzh\u013eadom na nebezpe\u010denstvo z\u00e1vislosti na opioidoch, zneu\u017e\u00edvania a nespr\u00e1vneho u\u017e\u00edvania, dokonca aj v povolen\u00fdch d\u00e1vkach, vyhra\u010fte ROXICODONE pre pacientov, ktor\u00ed nereaguj\u00fa na alternat\u00edvnu lie\u010dbu (napr. neopioidn\u00e9 analgetik\u00e1 alebo opioidn\u00e9 kombinovan\u00e9 produkty):<\/p>\n

Neboli tolerovan\u00e9 a je nepravdepodobn\u00e9, \u017ee bud\u00fa povolen\u00e9
Nepodali vhodn\u00fa analg\u00e9ziu alebo pravdepodobne nepodaj\u00fa adekv\u00e1tnu analg\u00e9ziu<\/p>\n

Tento materi\u00e1l je ur\u010den\u00fd len pre zdravotn\u00edckych pracovn\u00edkov v Spojen\u00fdch \u0161t\u00e1toch americk\u00fdch.
Kompletn\u00e9 inform\u00e1cie o predpisoch pre Spojen\u00e9 \u0161t\u00e1ty vr\u00e1tane upozornenia v r\u00e1m\u010deku.<\/p>\n

Sprievodca liekmi<\/p>\n

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D\u00d4LE\u017dIT\u00c9 BEZPE\u010cNOSTN\u00c9 INFORM\u00c1CIE<\/b><\/h2>\n
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  • VAROVANIE: Z\u00c1VISLOS\u0164, ZNEU\u017d\u00cdVANIE A ZNEU\u017d\u00cdVANIE; STRAT\u00c9GIA HODNOTENIA A ZMIER\u0147OVANIA RIZIKA (REMS); \u017dIVOT OHROZUJ\u00daCA DEPRESIA D\u00ddCHANIA; N\u00c1HODN\u00c9 PO\u017dITIE; NEONAT\u00c1LNY OPIOIDN\u00dd SYNDR\u00d3M; INTERAKCIA S CYTOCHROMOM P450 3A4; a RIZIK\u00c1 ZO S\u00da\u010cASN\u00c9HO U\u017d\u00cdVANIA S BENZneu\u017e\u00edvan\u00edm, zneu\u017e\u00edvan\u00edm a nespr\u00e1vnym u\u017e\u00edvan\u00edm l\u00e1tok\n

    ROXICODONE vystavuje pacientov a in\u00fdch pou\u017e\u00edvate\u013eov nebezpe\u010denstvu z\u00e1vislosti na opioidoch, zneu\u017e\u00edvania a nespr\u00e1vneho u\u017e\u00edvania, ktor\u00e9 m\u00f4\u017eu vies\u0165 k smrti v d\u00f4sledku pred\u00e1vkovania. Pred poskytnut\u00edm ROXICODONE zhodno\u0165te riziko ka\u017ed\u00e9ho pacienta a pravidelne monitorujte v\u0161etk\u00fdch pacientov, \u010di sa u nich nevyvinie ur\u010dit\u00e9 spr\u00e1vanie a stavy.<\/p>\n

    Strat\u00e9gia hodnotenia a zmier\u0148ovania rizika opioidn\u00fdch analget\u00edk (REMS)<\/p>\n

    The Food and Drug Administration (FDA) vy\u017eaduje REMS pre opioidn\u00e9 analgetik\u00e1 na overenie, \u010di pr\u00ednosy preva\u017euj\u00fa nad nebezpe\u010denstvom z\u00e1vislosti, zneu\u017e\u00edvania a nespr\u00e1vneho u\u017e\u00edvania. Farmaceutick\u00e9 spolo\u010dnosti, ktor\u00e9 schv\u00e1lili opioidn\u00e9 analgetick\u00e9 produkty, s\u00fa povinn\u00e9 spr\u00edstupni\u0165 poskytovate\u013eom zdravotnej starostlivosti vzdel\u00e1vacie programy v s\u00falade s REMS. Poskytovate\u013eom zdravotnej starostlivosti sa d\u00f4razne odpor\u00fa\u010da: \u2022 dokon\u010di\u0165 vzdel\u00e1vac\u00ed program v s\u00falade s REMS; \u2022 poradi\u0165 pacientom a\/alebo opatrovate\u013eom o bezpe\u010dnom pou\u017e\u00edvan\u00ed, z\u00e1va\u017en\u00fdch rizik\u00e1ch, skladovan\u00ed a likvid\u00e1cii t\u00fdchto produktov pri ka\u017edom predpise; \u2022 zd\u00f4razni\u0165 pacientom a opatrovate\u013eom d\u00f4le\u017eitos\u0165 \u010d\u00edtania Sprievodcu liekmi v\u017edy, ke\u010f ich lek\u00e1rnik poskytne; a \u2022 zv\u00e1\u017ei\u0165 \u010fal\u0161ie n\u00e1stroje na zlep\u0161enie bezpe\u010dnosti pacienta, dom\u00e1cnosti a komunity.<\/p>\n

    \u017divot ohrozuj\u00faca respira\u010dn\u00e1 depresia<\/p>\n

    ROXICODONE m\u00f4\u017ee sp\u00f4sobi\u0165 v\u00e1\u017enu, \u017eivot ohrozuj\u00facu alebo smrte\u013en\u00fa depresiu d\u00fdchania. D\u00e1vajte pozor na \u00fatlm d\u00fdchania, najm\u00e4 na za\u010diatku lie\u010dby ROXICODONE alebo pri zvy\u0161ovan\u00ed d\u00e1vky.<\/p>\n

    N\u00e1hodn\u00e1 konzum\u00e1cia<\/p>\n

    N\u00e1hodn\u00e9 po\u017eitie ROXICODONE, najm\u00e4 mladistv\u00fdmi, m\u00f4\u017ee vies\u0165 k smrte\u013en\u00e9mu pred\u00e1vkovaniu ROXICODONEM. <\/p>\n

    Syndr\u00f3m abstinen\u010dn\u00e9ho syndr\u00f3mu u novorodencov<\/p>\n

    Pred\u013a\u017een\u00e9 u\u017e\u00edvanie ROXICODONE po\u010das tehotenstva m\u00f4\u017ee vies\u0165 k syndr\u00f3mu z vysadenia opioidov u novorodencov, ktor\u00fd m\u00f4\u017ee by\u0165 smrte\u013en\u00fd, ak nie je v\u010das diagnostikovan\u00fd a lie\u010den\u00fd, a vy\u017eaduje si lie\u010dbu pod\u013ea neonatol\u00f3gie – \u0161pecifick\u00e9 postupy. Ak je u tehotnej \u017eeny nevyhnutn\u00e9 dlhodob\u00e9 u\u017e\u00edvanie opioidov, informujte ju o nebezpe\u010denstve neonat\u00e1lneho abstinen\u010dn\u00e9ho syndr\u00f3mu od opioidov a zabezpe\u010dte, aby bola k dispoz\u00edcii vhodn\u00e1 lie\u010dba.<\/p>\n

    Interakcia s Cytochr\u00f3mom P450 3A4<\/p>\n

    S\u00fabe\u017en\u00e9 u\u017e\u00edvanie ROXICODONE a v\u0161etk\u00fdch inhib\u00edtorov cytochr\u00f3mu P450 3A4 m\u00f4\u017ee vies\u0165 k zv\u00fd\u0161eniu plazmatick\u00fdch koncentr\u00e1ci\u00ed oxykod\u00f3nu, \u010do m\u00f4\u017ee zhor\u0161i\u0165 alebo pred\u013a\u017ei\u0165 nepr\u00edjemn\u00e9 reakcie a m\u00f4\u017ee vies\u0165 k potenci\u00e1lne smrte\u013en\u00e9mu \u00fatlmu d\u00fdchania. Okrem toho zastavenie s\u00fabe\u017ene pou\u017e\u00edvan\u00e9ho induktora cytochr\u00f3mu P450 3A4 m\u00f4\u017ee vies\u0165 k zv\u00fd\u0161eniu plazmatick\u00e9 hladiny oxykod\u00f3nu. Pacienti u\u017e\u00edvaj\u00faci ROXICODONE a ak\u00fdko\u013evek inhib\u00edtor alebo induktor CYP3A4 maj\u00fa by\u0165 starostlivo sledovan\u00ed.<\/p>\n

    D\u00f4sledky s\u00fabe\u017en\u00e9ho u\u017e\u00edvania s benzodiazep\u00ednmi alebo in\u00fdmi l\u00e1tkami tlmiacimi centr\u00e1lny nervov\u00fd syst\u00e9m<\/p>\n

    S\u00fabe\u017en\u00e9 u\u017e\u00edvanie opioidov s benzodiazep\u00ednmi alebo in\u00fdmi l\u00e1tkami tlmiacimi CNS alkohol, m\u00f4\u017ee ma\u0165 za n\u00e1sledok extr\u00e9mnu ospalos\u0165, \u00fatlm d\u00fdchania, k\u00f3mu alebo smr\u0165.<\/p>\n

    S\u00fabe\u017en\u00e9 pod\u00e1vanie ROXICODONE s benzodiazep\u00ednmi alebo in\u00fdmi l\u00e1tkami tlmiacimi CNS by malo by\u0165 vyhraden\u00e9 pre jedincov, ktor\u00ed nereaguj\u00fa na alternat\u00edvne terapeutick\u00e9 alternat\u00edvy.
    Udr\u017eujte d\u00e1vky a trvanie na minime.
    D\u00e1vajte pozor na pr\u00edznaky a sympt\u00f3my \u00fatlmu d\u00fdchania a \u00fatlmu u pacientov.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div><\/div>\n

     <\/p>\n

    KONTRAINDIK\u00c1CIE<\/h2>\n

    ROXICODONE je kontraindikovan\u00fd u pacientov s:<\/p>\n

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    • V\u00fdznamn\u00e1 respira\u010dn\u00e1 depresia<\/li>\n
    • Ak\u00fatna alebo \u0165a\u017ek\u00e1 bronchi\u00e1lna astma v nemonitorovanom prostred\u00ed alebo bez resuscit\u00e1cie vybavenie<\/li>\n
    • Zn\u00e1ma alebo suspektn\u00e1 gastrointestin\u00e1lna ob\u0161trukcia vr\u00e1tane paralytick\u00e9ho ilea<\/li>\n
    • Zn\u00e1ma precitlivenos\u0165 na oxykod\u00f3n<\/li>\n<\/ul>\n

      \u00a0UPOZORNENIA A BEZPE\u010cNOSTN\u00c9 OPATRENIA<\/h2>\n
        \n
      • ROXICODONE obsahuje oxykod\u00f3n, l\u00e1tku kontrolovan\u00fa pod\u013ea zoznamu II. ROXICODONE ako opioid vystavuje pou\u017e\u00edvate\u013eov rizik\u00e1m z\u00e1vislosti, zneu\u017e\u00edvania a nespr\u00e1vneho u\u017e\u00edvania.<\/li>\n
      • Pred predp\u00edsan\u00edm lieku ROXICODONE zhodno\u0165te u ka\u017ed\u00e9ho pacienta riziko z\u00e1vislosti, zneu\u017e\u00edvania alebo nespr\u00e1vneho pou\u017eitia a monitorujte v\u0161etk\u00fdch pacientov, ktor\u00ed dost\u00e1vaj\u00fa ROXICODONE. v\u00fdvoj tohto spr\u00e1vania a stavov.<\/li>\n
      • Aby sa zabezpe\u010dilo, \u017ee pr\u00ednosy opioidn\u00fdch analget\u00edk prev\u00e1\u017eia rizik\u00e1 z\u00e1vislosti, zneu\u017e\u00edvania a nespr\u00e1vneho u\u017e\u00edvania, \u00darad pre potraviny a lie\u010div\u00e1 (FDA) po\u017eaduje strat\u00e9giu hodnotenia a zmier\u0148ovania riz\u00edk ( REMS) pre tieto produkty. Pod\u013ea po\u017eiadaviek REMS musia farmaceutick\u00e9 spolo\u010dnosti so schv\u00e1len\u00fdmi opioidn\u00fdmi analgetikami spr\u00edstupni\u0165 poskytovate\u013eom zdravotnej starostlivosti vzdel\u00e1vacie programy v s\u00falade s REMS.<\/li>\n
      • Pri pou\u017e\u00edvan\u00ed lieku bola hl\u00e1sen\u00e1 v\u00e1\u017ena, \u017eivot ohrozuj\u00faca alebo smrte\u013en\u00e1 respira\u010dn\u00e1 depresia. opioidy, aj ke\u010f sa pou\u017e\u00edvaj\u00fa pod\u013ea odpor\u00fa\u010dan\u00ed. Pacienti s chronick\u00fdm p\u013e\u00facnym ochoren\u00edm, star\u0161\u00ed, kachektick\u00ed alebo oslaben\u00ed pacienti m\u00f4\u017eu by\u0165 vystaven\u00ed zv\u00fd\u0161en\u00e9mu riziku. Pozorne sledujte, najm\u00e4 po\u010das inici\u00e1cie a titr\u00e1cie.<\/li>\n
      • Opi\u00e1ty m\u00f4\u017eu sp\u00f4sobi\u0165 poruchy d\u00fdchania s\u00favisiace so sp\u00e1nkom vr\u00e1tane centr\u00e1lneho sp\u00e1nkov\u00e9ho apnoe (CSA) a hypox\u00e9mie s\u00favisiacej so sp\u00e1nkom. U\u017e\u00edvanie opi\u00e1tov zvy\u0161uje riziko CSA v z\u00e1vislosti od d\u00e1vky.<\/li>\n
      • N\u00e1hodn\u00e9 po\u017eitie \u010do i len jednej d\u00e1vky ROXICODONE, najm\u00e4 de\u0165mi, m\u00f4\u017ee ma\u0165 za n\u00e1sledok \u00fatlm d\u00fdchania a smr\u0165 v d\u00f4sledku pred\u00e1vkovania ROXICODONEM. Informujte pacientov, aby podnikli kroky na bezpe\u010dn\u00e9 uchov\u00e1vanie ROXICODONE. Exspirovan\u00fd, nechcen\u00fd alebo nepou\u017eit\u00fd ROXICODONE by sa mal zlikvidova\u0165 spl\u00e1chnut\u00edm nepou\u017eit\u00e9ho lieku do z\u00e1choda, ak nie je k dispoz\u00edcii mo\u017enos\u0165 sp\u00e4tn\u00e9ho odberu lieku.<\/li>\n
      • Po dlh\u0161om u\u017e\u00edvan\u00ed sa m\u00f4\u017ee vyskytn\u00fa\u0165 neonat\u00e1lny abstinen\u010dn\u00fd syndr\u00f3m od opioidov (NOWS). opioidov po\u010das tehotenstva. Sledujte u novorodencov pr\u00edznaky TERAZ a pod\u013ea toho sa spr\u00e1vajte; NOWS m\u00f4\u017ee by\u0165 \u017eivot ohrozuj\u00face, ak nie je rozpoznan\u00e9 a lie\u010den\u00e9 u novorodencov.<\/li>\n
      • Pri pou\u017e\u00edvan\u00ed inhib\u00edtorov CYP3A4 alebo vysadzovania induktorov CYP3A4 u pacientov lie\u010den\u00fdch ROXICODONE, pacientov v \u010dast\u00fdch intervaloch pozorne sledujte a zv\u00e1\u017ete zn\u00ed\u017eenie d\u00e1vky ROXICODONE, k\u00fdm sa liek nestabilizuje dosahuj\u00fa sa efekty. Pri pou\u017e\u00edvan\u00ed ROXICODONE s induktormi CYP3A4 alebo pri vysaden\u00ed inhib\u00edtorov CYP3A4 pacientov v \u010dast\u00fdch intervaloch pozorne sledujte a zv\u00e1\u017ete zv\u00fd\u0161enie d\u00e1vky opioidov, ak je to potrebn\u00e9 na udr\u017eanie primeranej analg\u00e9zie alebo ak sa objavia pr\u00edznaky abstinencie od opioidov.<\/li>\n
      • Hlbok\u00e1 sed\u00e1cia, \u00fatlm d\u00fdchania, k\u00f3ma a smr\u0165 m\u00f4\u017ee nasta\u0165 v d\u00f4sledku s\u00fa\u010dasn\u00e9ho u\u017e\u00edvania ROXICODONE s benzodiazep\u00ednmi alebo in\u00fdmi l\u00e1tkami tlmiacimi CNS (vr\u00e1tane alkoholu a\u00a0ileg\u00e1lnych drog).<\/li>\n
      • Pri u\u017e\u00edvan\u00ed opi\u00e1tov boli hl\u00e1sen\u00e9 pr\u00edpady adren\u00e1lnej insuficiencie, \u010dastej\u0161ie po viac ako 1 mesiac pou\u017e\u00edvania. Ak je diagnostikovan\u00e1 adren\u00e1lna insuficiencia, lie\u010dte fyziologickou n\u00e1hradou kortikosteroidov a odstavte pacienta opioidu, k\u00fdm sa funkcia nadobli\u010diek neobnov\u00ed.<\/li>\n
      • ROXICODONE<\/strong>\u00a0m\u00f4\u017ee sp\u00f4sobi\u0165 \u0165a\u017ek\u00fa \u200b\u200bhypotenziu vr\u00e1tane ortostatickej hypotenzie a synkopy u ambulantn\u00fdch pacientov. Monitorujte po\u010das za\u010datia a\/alebo titr\u00e1cie ROXICODONE. Vyhnite sa pou\u017e\u00edvaniu u pacientov s obehov\u00fdm \u0161okom.<\/li>\n
      • Pou\u017e\u00edvanie u pacientov so zv\u00fd\u0161en\u00fdm intrakrani\u00e1lnym tlakom, mozgov\u00fdmi n\u00e1dormi, poranen\u00edm hlavy alebo zhor\u0161en\u00fdm vedom\u00edm m\u00f4\u017ee zn\u00ed\u017ei\u0165 d\u00fdchanie a v\u00fdsledn\u00fa retenciu CO2<\/sub>\u00a0m\u00f4\u017ee \u010falej zvy\u0161ova\u0165 intrakrani\u00e1lny tlak. U\u017e\u00edvaniu\u00a0ROXICODONE<\/strong>\u00a0je potrebn\u00e9 sa vyhn\u00fa\u0165 u pacientov s poruchou vedomia alebo k\u00f3mou.<\/li>\n
      • ROXICODONE je kontraindikovan\u00fd u pacientov so zn\u00e1mou alebo suspektnou gastrointestin\u00e1lnou ob\u0161trukciou vr\u00e1tane paralytick\u00e9ho ilea. Oxykod\u00f3n v ROXICODONE m\u00f4\u017ee sp\u00f4sobi\u0165 k\u0155\u010de Oddiho zviera\u010da.<\/li>\n
      • Oxykod\u00f3n v ROXICODONE m\u00f4\u017ee zv\u00fd\u0161i\u0165 frekvenciu z\u00e1chvatov u pacientov so z\u00e1chvatov\u00fdmi poruchami a m\u00f4\u017ee zv\u00fd\u0161i\u0165 riziko z\u00e1chvatov vyskytuj\u00facich sa v in\u00fdch klinick\u00fdch podmienkach spojen\u00fdch so z\u00e1chvatmi . Monitorujte pacientov s anamn\u00e9zou z\u00e1chvatov\u00fdch por\u00fach kv\u00f4li zhor\u0161eniu kontroly z\u00e1chvatov.<\/li>\n
      • Nepreru\u0161ujte n\u00e1hle u\u017e\u00edvanie\u00a0ROXICODONE<\/strong>\u00a0u pacienta fyzicky z\u00e1visl\u00e9ho od opioidov. Pri vysaden\u00ed ROXICODONE u fyzicky z\u00e1visl\u00e9ho pacienta d\u00e1vku postupne zni\u017eujte. R\u00fdchle zni\u017eovanie d\u00e1vky oxykod\u00f3nu u pacienta fyzicky z\u00e1visl\u00e9ho na opioidoch m\u00f4\u017ee vies\u0165 k abstinen\u010dn\u00e9mu syndr\u00f3mu a n\u00e1vratu bolesti.<\/li>\n
      • Vyhnite sa pou\u017e\u00edvaniu ROXICODONE so zmie\u0161an\u00fdmi agonistami\/antagonistami alebo \u010diasto\u010dne agonistick\u00fdmi analgetikami kv\u00f4li riziku precipit\u00e1cie abstinen\u010dn\u00e9 pr\u00edznaky.<\/li>\n
      • Upozornite pacientov, aby neviedli vozidlo ani neobsluhovali nebezpe\u010dn\u00e9 stroje, pokia\u013e nie s\u00fa tolerantn\u00ed vo\u010di \u00fa\u010dinkom ROXICODONE a nevedia, ako bud\u00fa na liek reagova\u0165.<\/li>\n
      • Opi\u00e1ty m\u00f4\u017eu sp\u00f4sobi\u0165 zriedkav\u00e9 ale potenci\u00e1lne \u017eivot ohrozuj\u00faci stav vypl\u00fdvaj\u00faci zo s\u00fabe\u017en\u00e9ho pod\u00e1vania serotonergn\u00fdch liekov. Upozornite pacientov na sympt\u00f3my seroton\u00ednov\u00e9ho syndr\u00f3mu a ak sa sympt\u00f3my rozvin\u00fa, ihne\u010f vyh\u013eadajte lek\u00e1rsku pomoc.<\/li>\n
      • Pou\u017e\u00edvanie ROXICODONE sa neodpor\u00fa\u010da pacientom u\u017e\u00edvaj\u00facim IMAO alebo do 14 dn\u00ed po ukon\u010den\u00ed takejto lie\u010dby.<\/li>\n<\/ul>\n

        \u00da\u010dinky Roxicodonu<\/h2>\n

        Z\u00e1va\u017en\u00e9 ne\u017eiaduce reakcie spojen\u00e9 s u\u017e\u00edvan\u00edm ROXICODONE zah\u0155\u0148aj\u00fa \u00fatlm d\u00fdchania, zastavenie d\u00fdchania, \u00fatlm obehu, zastavenie srdca, hypotenziu a\/alebo \u0161ok. Medzi naj\u010dastej\u0161ie ne\u017eiaduce reakcie patr\u00ed nauzea, z\u00e1pcha, vracanie, boles\u0165 hlavy, pruritus, nespavos\u0165, z\u00e1vraty, ast\u00e9nia a ospalos\u0165.<\/p>\n

        Toto nie je \u00fapln\u00fd zoznam potenci\u00e1lnych ne\u017eiaducich udalost\u00ed spojen\u00fdch s ROXICODONE. \u00dapln\u00fd zoznam n\u00e1jdete v \u00dapln\u00fdch inform\u00e1ci\u00e1ch o predpisovan\u00ed.<\/p>\n

         <\/p>\n

         <\/p>\n<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n

        \n
        \n\n\n\n\n\n\n
        Popis<\/strong><\/td>\nModr\u00e9 tablety s deliacou ryhou<\/td>\n<\/tr>\n
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        \n
        <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

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