{"id":5926,"date":"2022-02-22T08:28:02","date_gmt":"2022-02-22T08:28:02","guid":{"rendered":"https:\/\/medicinasinc.com\/ro\/?post_type=product&#038;p=5926"},"modified":"2022-03-22T00:44:26","modified_gmt":"2022-03-22T00:44:26","slug":"cumpara-thj-018","status":"publish","type":"product","link":"https:\/\/medicinasinc.com\/ro\/product\/cumpara-thj-018\/","title":{"rendered":"Cump\u0103ra\u021bi THJ-018"},"content":{"rendered":"<p>\u00cen ciuda prevalen\u021bei \u00een cre\u0219tere a noilor compu\u0219i psihoactivi, \u00een prezent nu exist\u0103 date disponibile despre metabolismul uman, ceea ce face documentarea de laborator a inger\u0103rii \u00een probele de urin\u0103 \u0219i evaluarea caracteristicilor farmacodinamice, farmacocinetice \u0219i toxicologice ale medicamentelor.<\/p>\n<p>Analogii sintetici de indazol de canabis ai JWH-018 \u0219i THJ-2201 au fost lansati \u00een 2014 ca THJ-018 \u0219i THJ-2201.<\/p>\n<p>THJ 018 este un medicament sintetic nou-nou\u021b disponibil pentru cump\u0103rare. Este clasificat drept canabinoid. Acest compus este un derivat al cunoscutului medicament jwh 018.<\/p>\n<p>Sistemul de informa\u021bii al Laboratorului Na\u021bional de Medicin\u0103 Legal\u0103 are 220 de rapoarte THJ-2201, conform AM-2201. \u00cen ianuarie 2015, Drug Enforcement Administration a clasificat THJ-2201 ca Lista I din cauza multor evenimente adverse.<\/p>\n<p>METODE: Dup\u0103 incubarea a 10 mol\/L THJ-018 \u0219i THJ-2201 \u00een hepatocite umane timp de 3 ore, am folosit spectrometrie de mas\u0103 de \u00eenalt\u0103 rezolu\u021bie (HR-MS) (TripleTOF 5600+) pentru a descoperi markeri optimi de metaboli\u021bi. Scan\u0103rile de ioni de produs cu filtre de defect de mas\u0103 au fost activate prin scanare complet\u0103 \u0219i achizi\u021bie dependent\u0103 de informa\u021bii. MetaSite a fost folosit pentru a face predic\u021bii in silico de metaboli\u021bi, care au fost apoi compara\u021bi cu metaboli\u021bii g\u0103si\u021bi \u00een hepatocitele umane.<\/p>\n<p>REZULTATE: Au fost g\u0103si\u021bi treisprezece metaboli\u021bi THJ-018, cu hidroxilare pe lan\u021bul N-pentil \u0219i oxidare ulterioar\u0103 sau glucuronidarea fiind c\u0103ile metabolice predominante. Au fost g\u0103si\u021bi 27 de metaboli\u021bi \u00een THJ-2201, majoritatea fiind defluorurarea oxidativ\u0103 urmat\u0103 de carboxilare sau glucuronidare, precum \u0219i glucuronidarea metaboli\u021bilor hidroxila\u021bi.<\/p>\n<p>Ambele compu\u0219i au prezentat sinteza dihidrodiol pe por\u021biunea naftalen\u0103. Predic\u021bia MetaSite a fost precis\u0103 pentru metaboli\u021bii hepatocitelor THJ-018, \u00een timp ce defluorinarea oxidativ\u0103 a THJ-2201 a fost subestimat\u0103.<\/p>\n<p>CONCLUZII: Am investigat metabolismul THJ-018 \u0219i THJ-2201 \u00een hepatocitele umane folosind HR-MS pentru achizi\u021bia de date \u0219i procesare \u0219i recomand\u0103m indicatori relevan\u021bi pentru laboratoare pentru a identifica ingestia de THJ-018 \u0219i THJ-2201 \u0219i pentru a lega rezultatele adverse documentate cu ace\u0219ti noi canabinoizi sintetici.<\/p>\n<p>SC se leag\u0103 de receptorii canabinoizi endogeni \u0219i produc efecte canabimimetice comparabile cu 9 -tetrahidrocannabinol (1, 2). Abuzul de SC3 duce la efecte secundare majore, cum ar fi afectarea renal\u0103 acut\u0103, infarctul miocardic \u0219i moartea (3, 4).<\/p>\n<p>\u00cen ciuda acestor riscuri, oamenii continu\u0103 s\u0103 consume SC. Multe SC au fost programate \u00een Statele Unite, Japonia \u0219i majoritatea na\u021biunilor europene (de exemplu, JWH018, JWH-073, AKB48 \u0219i XLR-11); cu toate acestea, compu\u0219i suplimentari varia\u021bi din punct de vedere structural apar \u00een mod constant.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cump\u0103ra\u021bi THJ-018 (SGT-17) de v\u00e2nzare \u00een Europa, Marea Britanie este un canabinoid sintetic care este analogul indazol al lui JWH-018 \u0219i a fost v\u00e2ndut online ca medicament de design. Comanda angro disponibil\u0103<\/p>\n","protected":false},"featured_media":5940,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[2596],"product_tag":[4103,4107,4105,4104,4106,4109,4108],"class_list":{"0":"post-5926","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-canabinoizi-de-vnzare","7":"product_tag-buy-thj-018-online","8":"product_tag-cel-mai-bun-loc-de-cumprare-thj-018-online","9":"product_tag-comanda-thj-018-online","10":"product_tag-cum-se-cumpr-thj-018-online","11":"product_tag-cumprare-thj-018-online","12":"product_tag-unde-s-cumprm-thj-018-online","13":"product_tag-thj-018-de-vnzare","15":"first","16":"instock","17":"shipping-taxable","18":"purchasable","19":"product-type-variable"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cump\u0103ra\u021bi THJ-018 - SGT-17 - Cele mai bune medicamente globale<\/title>\n<meta name=\"description\" content=\"Cump\u0103ra\u021bi THJ-018 (SGT-17) de v\u00e2nzare Europa, Marea Britanie este un canabinoid sintetic care este analogul indazol al lui JWH-018 \u0219i a fost v\u00e2ndut online ca medicament de design. 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