{"id":5902,"date":"2022-02-22T08:09:55","date_gmt":"2022-02-22T08:09:55","guid":{"rendered":"https:\/\/medicinasinc.com\/no\/?post_type=product&p=5902"},"modified":"2022-03-22T00:39:50","modified_gmt":"2022-03-22T00:39:50","slug":"kjop-5f-adb","status":"publish","type":"product","link":"https:\/\/medicinasinc.com\/no\/product\/kjop-5f-adb\/","title":{"rendered":"Kj\u00f8p 5F-ADB"},"content":{"rendered":"

5F-ADB (alternativt stavet 5F-MDMB-PINACA) er en syntetisk cannabinoid avledet fra indazol som har blitt brukt som en aktiv ingrediens i syntetiske cannabisprodukter og solgt p\u00e5 nettet som et designermedikament.<\/p>\n

5F -ADB er en sterk agonist av CB1-reseptoren, selv om dens selektivitet for denne reseptoren er ukjent. 5F-ADB ble funnet for f\u00f8rste gang i november 2014 ved bruk av obduksjonspr\u00f8ver fra en person som d\u00f8de etter \u00e5 ha tatt et produkt som inneholder dette stoffet. Etterf\u00f8lgende testing avsl\u00f8rte at 5F-ADB ble oppdaget hos totalt ti personer som d\u00f8de i Japan mellom september og desember 2014 av uforklarlige overdoser med stoff. Basert p\u00e5 de relativt lave niv\u00e5ene som ble oppdaget i vevstester, antas 5F-ADB \u00e5 v\u00e6re ekstraordin\u00e6rt sterk og ser ut til \u00e5 v\u00e6re betydelig mer farlig enn tidligere solgte syntetiske cannabismedisiner.<\/p>\n

N-[[1-(5- fluorpentyl)-1H-indazol-3-yl]karbonyl]<\/p>\n

-3-metyl-D-valin metylester (5F-ADB) er en sv\u00e6rt sterk syntetisk cannabis som for\u00e5rsaker alvorlige psykotiske symptomer hos mennesker, av og til d\u00f8delig.<\/p>\n

For \u00e5 belyse de nevronale mekanismene bak 5F-toksisitet, studerte ADBs effektene p\u00e5 mellomhjernens dopaminerge og serotonerge kretser, som regulerer en rekke grunnleggende hjernefunksjoner, inkludert de som er forbundet med bel\u00f8nningsrelatert atferd. Ex vivo elektrofysiologiske teknikker ble brukt for \u00e5 registrere endringer i den spontane avfyringsaktiviteten til dopaminerge og serotonerge nevroner produsert av 5F-ADB.<\/p>\n

5F-ADB (1 M) \u00f8kte den spontane avfyringshastigheten til dopaminerge nevroner dramatisk, men klarte ikke \u00e5 aktivere dem i n\u00e6rv\u00e6r av CB1-antagonisten AM251 (1 M). Den samme konsentrasjonen av 5F-ADB hadde derimot ingen effekt p\u00e5 serotonerg nevronaktivitet. Disse funnene viser at 5F-ADB aktiverer lokale CB1-reseptorer og forbedrer dopaminerge systemer i midthjernen, samtidig som det ikke har noen effekt p\u00e5 serotonerge systemer i midthjernen.<\/p>\n","protected":false},"excerpt":{"rendered":"

Kj\u00f8p 5F-ADB for salg Storbritannia, Europa, Kina (ogs\u00e5 kjent som 5F-MDMB-PINACA) er en indazol-basert syntetisk cannabinoid fra indazol-3-karboksamidfamilien, engrosordre tilgjengelig<\/p>\n","protected":false},"featured_media":5933,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[2596],"product_tag":[4066,4068,4067,4069,4073,4070,4071,4074,4072,4076,4075],"class_list":{"0":"post-5902","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-cannabinoider-til-salg","7":"product_tag-5f-adb","8":"product_tag-5f-adb-pulver","9":"product_tag-5f-adb-til-salgs","10":"product_tag-5f-mdmb-pinaca","11":"product_tag-bestille-5f-adb-online","12":"product_tag-buy-5f-adb-online","13":"product_tag-c20h28fn3o3","14":"product_tag-det-beste-stedet--kjpe-5f-adb-online","15":"product_tag-how-to-buy-5f-adb-online","16":"product_tag-hvor-kan-kjpe-5f-adb-online","17":"product_tag-v1715016-75-3","19":"first","20":"instock","21":"featured","22":"shipping-taxable","23":"purchasable","24":"product-type-variable"},"yoast_head":"\nKj\u00f8p 5F-ADB - 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