{"id":5926,"date":"2022-02-22T08:28:02","date_gmt":"2022-02-22T08:28:02","guid":{"rendered":"https:\/\/medicinasinc.com\/lv\/?post_type=product&#038;p=5926"},"modified":"2022-07-05T22:46:05","modified_gmt":"2022-07-05T22:46:05","slug":"pirkt-thj-018","status":"publish","type":"product","link":"https:\/\/medicinasinc.com\/lv\/product\/pirkt-thj-018\/","title":{"rendered":"P\u0113rciet THJ-018"},"content":{"rendered":"<p>Neskatoties uz pieaugo\u0161o jauno psihoakt\u012bvo savienojumu izplat\u012bbu, pa\u0161laik nav pieejami dati par cilv\u0113ka metabolismu, kas apgr\u016btina laboratorisko dokument\u0101ciju par nor\u012b\u0161anu ur\u012bna paraugos un z\u0101\u013cu farmakodinamisko, farmakokin\u0113tisko un toksikolo\u0123isko \u012bpa\u0161\u012bbu nov\u0113rt\u0113\u0161anu.<\/p>\n<p>Sint\u0113tiskie ka\u0146epju indazola analogi JWH-018 un THJ-2201 tika izlaisti 2014.\u00a0gad\u0101 k\u0101 THJ-018 un THJ-2201.<\/p>\n<p>THJ 018 ir piln\u012bgi jauns sint\u0113tisks medikaments, ko var ieg\u0101d\u0101ties. Tas ir klasific\u0113ts k\u0101 kanabino\u012bds. \u0160is savienojums ir labi zin\u0101m\u0101s z\u0101les jwh 018 atvasin\u0101jums.<\/p>\n<p>Saska\u0146\u0101 ar AM-2201 Nacion\u0101laj\u0101 krimin\u0101listikas laboratorijas inform\u0101cijas sist\u0113m\u0101 ir 220\u00a0THJ-2201 zi\u0146ojumi. 2015.\u00a0gada janv\u0101r\u012b Narkotiku apkaro\u0161anas p\u0101rvalde daudzu nev\u0113lamu notikumu d\u0113\u013c klasific\u0113ja THJ-2201 k\u0101 I sarakstu.<\/p>\n<p>METODES: p\u0113c 10 mol\/L THJ-018 un THJ-2201 inkub\u0101cijas cilv\u0113ka hepatoc\u012btos 3 stundas, m\u0113s izmantoj\u0101m augstas iz\u0161\u0137irtsp\u0113jas masas spektrometriju (HR-MS) (TripleTOF 5600+), lai atkl\u0101tu optim\u0101los metabol\u012btu mar\u0137ierus. Produkta jonu sken\u0113\u0161ana ar masas defektu filtriem tika aktiviz\u0113ta, veicot piln\u012bgu sken\u0113\u0161anu un no inform\u0101cijas atkar\u012bgu ieg\u016b\u0161anu. MetaSite tika izmantots, lai prognoz\u0113tu in silico metabol\u012btus, kas p\u0113c tam tika sal\u012bdzin\u0101ti ar metabol\u012btiem, kas atrodami cilv\u0113ka hepatoc\u012btos.<\/p>\n<p>REZULT\u0100TI: tika atrasti tr\u012bspadsmit THJ-018 metabol\u012bti ar hidroksil\u0101ciju N-pentila \u0137\u0113d\u0113 un sekojo\u0161u oksid\u0101ciju vai glikuroniz\u0101cija ir domin\u0113jo\u0161ie vielmai\u0146as ce\u013ci. THJ-2201 tika atrasti 27 metabol\u012bti, no kuriem liel\u0101k\u0101 da\u013ca bija oksidat\u012bv\u0101 defluor\u0113\u0161ana, kam sekoja karboksil\u0113\u0161ana vai glikuroniz\u0101cija, k\u0101 ar\u012b hidroksil\u0113to metabol\u012btu glikuroniz\u0101cija.<\/p>\n<p>Abi savienojumi uzr\u0101d\u012bja dihidrodiola sint\u0113zi naftal\u012bna da\u013c\u0101. MetaSite prognoze bija prec\u012bza attiec\u012bb\u0101 uz THJ-018 hepatoc\u012btu metabol\u012btiem, savuk\u0101rt THJ-2201 oksidat\u012bv\u0101 defluor\u0113\u0161ana tika nov\u0113rt\u0113ta par zemu.<\/p>\n<p>SECIN\u0100JUMI. M\u0113s p\u0113t\u012bj\u0101m THJ-018 un THJ-2201 metabolismu cilv\u0113ka hepatoc\u012btos, izmantojot HR-MS datu ieg\u016b\u0161anai un ieg\u016b\u0161anai. apstr\u0101di, un m\u0113s iesak\u0101m laboratorij\u0101m izmantot atbilsto\u0161us indikatorus, lai identific\u0113tu THJ-018 un THJ-2201 nor\u012b\u0161anu un saist\u012btu dokument\u0113tos nelabv\u0113l\u012bgos rezult\u0101tus ar \u0161iem jaunajiem sint\u0113tiskajiem kanabino\u012bdiem.<\/p>\n<p>SC saist\u0101s ar endog\u0113niem kanabino\u012bdu receptoriem un rada kanabimim\u0113tiskos efektus, kas ir sal\u012bdzin\u0101mi ar 9. -tetrahidrokanabinols (1, 2). SC3 \u013caunpr\u0101t\u012bga izmanto\u0161ana izraisa nopietnas blakuspar\u0101d\u012bbas, piem\u0113ram, ak\u016btu nieru boj\u0101jumu, miokarda infarktu un n\u0101vi (3, 4).<\/p>\n<p>Neskatoties uz \u0161iem riskiem, cilv\u0113ki turpina lietot SC. Daudzi SC ir iepl\u0101noti ASV, Jap\u0101n\u0101 un liel\u0101kaj\u0101 da\u013c\u0101 Eiropas valstu (piem\u0113ram, JWH018, JWH-073, AKB48 un XLR-11); tom\u0113r past\u0101v\u012bgi par\u0101d\u0101s papildu struktur\u0101li da\u017e\u0101di savienojumi.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>P\u0113rciet THJ-018 (SGT-17) p\u0101rdo\u0161anai Eirop\u0101, Apvienotaj\u0101 Karalist\u0113 ir sint\u0113tisks kanabino\u012bds, kas ir JWH-018 indazola analogs un ir p\u0101rdots tie\u0161saist\u0113 k\u0101 dizaineru z\u0101les. Pieejams vairumtirdzniec\u012bbas pas\u016bt\u012bjums<\/p>\n","protected":false},"featured_media":5940,"comment_status":"open","ping_status":"closed","template":"","meta":{"_members_access_role":[],"_members_access_error":""},"product_brand":[],"product_cat":[2596],"product_tag":[4103,4106,4104,4109,4107,4108,4105],"class_list":["post-5926","product","type-product","status-publish","has-post-thumbnail","product_cat-pardodu-kanabinoidus","product_tag-buy-thj-018-online","product_tag-pirkums-thj-018-tiesaist","product_tag-k-iegdties-thj-018-tiesaist","product_tag-kur-nopirkt-thj-018-tiesaist","product_tag-labk-vieta-kur-pirkt-thj-018-tiesaist","product_tag-thj-018-prdoanai","product_tag-pastt-thj-018-tiesaist","first","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>P\u0113rciet THJ-018\u00a0\u2014 SGT-17\u00a0\u2014 lab\u0101k\u0101s pasaules lab\u0101k\u0101s z\u0101les<\/title>\n<meta name=\"description\" content=\"P\u0113rciet THJ-018 (SGT-17) p\u0101rdo\u0161anai Eirop\u0101, Apvienotaj\u0101 Karalist\u0113 ir sint\u0113tisks kanabino\u012bds, kas ir JWH-018 indazola analogs un ir p\u0101rdots tie\u0161saist\u0113 k\u0101 dizaineru z\u0101les. Pieejams vairumtirdzniec\u012bbas pas\u016bt\u012bjums\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicinasinc.com\/lv\/product\/pirkt-thj-018\/\" \/>\n<meta property=\"og:locale\" content=\"lv_LV\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"P\u0113rciet THJ-018\u00a0\u2014 SGT-17\u00a0\u2014 lab\u0101k\u0101s pasaules lab\u0101k\u0101s z\u0101les\" \/>\n<meta property=\"og:description\" content=\"P\u0113rciet THJ-018 (SGT-17) p\u0101rdo\u0161anai Eirop\u0101, Apvienotaj\u0101 Karalist\u0113 ir sint\u0113tisks kanabino\u012bds, kas ir JWH-018 indazola analogs un ir p\u0101rdots tie\u0161saist\u0113 k\u0101 dizaineru z\u0101les. Pieejams vairumtirdzniec\u012bbas pas\u016bt\u012bjums\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicinasinc.com\/lv\/product\/pirkt-thj-018\/\" \/>\n<meta property=\"og:site_name\" content=\"Medicinas Inc\" \/>\n<meta property=\"article:modified_time\" content=\"2022-07-05T22:46:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/medicinasinc.com\/lv\/wp-content\/uploads\/sites\/19\/2022\/02\/Buy-THJ-018.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"751\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 min\u016btes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medicinasinc.com\\\/lv\\\/product\\\/pirkt-thj-018\\\/\",\"url\":\"https:\\\/\\\/medicinasinc.com\\\/lv\\\/product\\\/pirkt-thj-018\\\/\",\"name\":\"P\u0113rciet THJ-018\u00a0\u2014 SGT-17\u00a0\u2014 lab\u0101k\u0101s pasaules lab\u0101k\u0101s z\u0101les\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medicinasinc.com\\\/lv\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/medicinasinc.com\\\/lv\\\/product\\\/pirkt-thj-018\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/medicinasinc.com\\\/lv\\\/product\\\/pirkt-thj-018\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/medicinasinc.com\\\/lv\\\/wp-content\\\/uploads\\\/sites\\\/19\\\/2022\\\/02\\\/Buy-THJ-018.jpeg\",\"datePublished\":\"2022-02-22T08:28:02+00:00\",\"dateModified\":\"2022-07-05T22:46:05+00:00\",\"description\":\"P\u0113rciet THJ-018 (SGT-17) p\u0101rdo\u0161anai Eirop\u0101, Apvienotaj\u0101 Karalist\u0113 ir sint\u0113tisks kanabino\u012bds, kas ir JWH-018 indazola analogs un ir p\u0101rdots tie\u0161saist\u0113 k\u0101 dizaineru z\u0101les. Pieejams vairumtirdzniec\u012bbas pas\u016bt\u012bjums\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/medicinasinc.com\\\/lv\\\/product\\\/pirkt-thj-018\\\/#breadcrumb\"},\"inLanguage\":\"lv-LV\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/medicinasinc.com\\\/lv\\\/product\\\/pirkt-thj-018\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"lv-LV\",\"@id\":\"https:\\\/\\\/medicinasinc.com\\\/lv\\\/product\\\/pirkt-thj-018\\\/#primaryimage\",\"url\":\"https:\\\/\\\/medicinasinc.com\\\/lv\\\/wp-content\\\/uploads\\\/sites\\\/19\\\/2022\\\/02\\\/Buy-THJ-018.jpeg\",\"contentUrl\":\"https:\\\/\\\/medicinasinc.com\\\/lv\\\/wp-content\\\/uploads\\\/sites\\\/19\\\/2022\\\/02\\\/Buy-THJ-018.jpeg\",\"width\":751,\"height\":800},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/medicinasinc.com\\\/lv\\\/product\\\/pirkt-thj-018\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Veikals\",\"item\":\"https:\\\/\\\/medicinasinc.com\\\/lv\\\/veikals\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"P\u0113rciet THJ-018\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/medicinasinc.com\\\/lv\\\/#website\",\"url\":\"https:\\\/\\\/medicinasinc.com\\\/lv\\\/\",\"name\":\"Medicinas Inc\",\"description\":\"Health Medical Clinic\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/medicinasinc.com\\\/lv\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"lv-LV\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"P\u0113rciet THJ-018\u00a0\u2014 SGT-17\u00a0\u2014 lab\u0101k\u0101s pasaules lab\u0101k\u0101s z\u0101les","description":"P\u0113rciet THJ-018 (SGT-17) p\u0101rdo\u0161anai Eirop\u0101, Apvienotaj\u0101 Karalist\u0113 ir sint\u0113tisks kanabino\u012bds, kas ir JWH-018 indazola analogs un ir p\u0101rdots tie\u0161saist\u0113 k\u0101 dizaineru z\u0101les. Pieejams vairumtirdzniec\u012bbas pas\u016bt\u012bjums","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/medicinasinc.com\/lv\/product\/pirkt-thj-018\/","og_locale":"lv_LV","og_type":"article","og_title":"P\u0113rciet THJ-018\u00a0\u2014 SGT-17\u00a0\u2014 lab\u0101k\u0101s pasaules lab\u0101k\u0101s z\u0101les","og_description":"P\u0113rciet THJ-018 (SGT-17) p\u0101rdo\u0161anai Eirop\u0101, Apvienotaj\u0101 Karalist\u0113 ir sint\u0113tisks kanabino\u012bds, kas ir JWH-018 indazola analogs un ir p\u0101rdots tie\u0161saist\u0113 k\u0101 dizaineru z\u0101les. Pieejams vairumtirdzniec\u012bbas pas\u016bt\u012bjums","og_url":"https:\/\/medicinasinc.com\/lv\/product\/pirkt-thj-018\/","og_site_name":"Medicinas Inc","article_modified_time":"2022-07-05T22:46:05+00:00","og_image":[{"width":751,"height":800,"url":"https:\/\/medicinasinc.com\/lv\/wp-content\/uploads\/sites\/19\/2022\/02\/Buy-THJ-018.jpeg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 min\u016btes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/medicinasinc.com\/lv\/product\/pirkt-thj-018\/","url":"https:\/\/medicinasinc.com\/lv\/product\/pirkt-thj-018\/","name":"P\u0113rciet THJ-018\u00a0\u2014 SGT-17\u00a0\u2014 lab\u0101k\u0101s pasaules lab\u0101k\u0101s z\u0101les","isPartOf":{"@id":"https:\/\/medicinasinc.com\/lv\/#website"},"primaryImageOfPage":{"@id":"https:\/\/medicinasinc.com\/lv\/product\/pirkt-thj-018\/#primaryimage"},"image":{"@id":"https:\/\/medicinasinc.com\/lv\/product\/pirkt-thj-018\/#primaryimage"},"thumbnailUrl":"https:\/\/medicinasinc.com\/lv\/wp-content\/uploads\/sites\/19\/2022\/02\/Buy-THJ-018.jpeg","datePublished":"2022-02-22T08:28:02+00:00","dateModified":"2022-07-05T22:46:05+00:00","description":"P\u0113rciet THJ-018 (SGT-17) p\u0101rdo\u0161anai Eirop\u0101, Apvienotaj\u0101 Karalist\u0113 ir sint\u0113tisks kanabino\u012bds, kas ir JWH-018 indazola analogs un ir p\u0101rdots tie\u0161saist\u0113 k\u0101 dizaineru z\u0101les. Pieejams vairumtirdzniec\u012bbas pas\u016bt\u012bjums","breadcrumb":{"@id":"https:\/\/medicinasinc.com\/lv\/product\/pirkt-thj-018\/#breadcrumb"},"inLanguage":"lv-LV","potentialAction":[{"@type":"ReadAction","target":["https:\/\/medicinasinc.com\/lv\/product\/pirkt-thj-018\/"]}]},{"@type":"ImageObject","inLanguage":"lv-LV","@id":"https:\/\/medicinasinc.com\/lv\/product\/pirkt-thj-018\/#primaryimage","url":"https:\/\/medicinasinc.com\/lv\/wp-content\/uploads\/sites\/19\/2022\/02\/Buy-THJ-018.jpeg","contentUrl":"https:\/\/medicinasinc.com\/lv\/wp-content\/uploads\/sites\/19\/2022\/02\/Buy-THJ-018.jpeg","width":751,"height":800},{"@type":"BreadcrumbList","@id":"https:\/\/medicinasinc.com\/lv\/product\/pirkt-thj-018\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Veikals","item":"https:\/\/medicinasinc.com\/lv\/veikals\/"},{"@type":"ListItem","position":2,"name":"P\u0113rciet THJ-018"}]},{"@type":"WebSite","@id":"https:\/\/medicinasinc.com\/lv\/#website","url":"https:\/\/medicinasinc.com\/lv\/","name":"Medicinas Inc","description":"Health Medical Clinic","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/medicinasinc.com\/lv\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"lv-LV"}]}},"_links":{"self":[{"href":"https:\/\/medicinasinc.com\/lv\/wp-json\/wp\/v2\/product\/5926","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicinasinc.com\/lv\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medicinasinc.com\/lv\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medicinasinc.com\/lv\/wp-json\/wp\/v2\/comments?post=5926"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medicinasinc.com\/lv\/wp-json\/wp\/v2\/media\/5940"}],"wp:attachment":[{"href":"https:\/\/medicinasinc.com\/lv\/wp-json\/wp\/v2\/media?parent=5926"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medicinasinc.com\/lv\/wp-json\/wp\/v2\/product_brand?post=5926"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medicinasinc.com\/lv\/wp-json\/wp\/v2\/product_cat?post=5926"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medicinasinc.com\/lv\/wp-json\/wp\/v2\/product_tag?post=5926"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}