{"id":5902,"date":"2022-02-22T08:09:55","date_gmt":"2022-02-22T08:09:55","guid":{"rendered":"https:\/\/medicinasinc.com\/fi\/?post_type=product&p=5902"},"modified":"2022-03-22T00:45:25","modified_gmt":"2022-03-22T00:45:25","slug":"osta-5f-adb","status":"publish","type":"product","link":"https:\/\/medicinasinc.com\/fi\/product\/osta-5f-adb\/","title":{"rendered":"Osta 5F-ADB"},"content":{"rendered":"

5F-ADB (vaihtoehtoisesti kirjoitettu 5F-MDMB-PINACA) on indatsolista johdettu synteettinen kannabinoidi, jota on k\u00e4ytetty aktiivisena aineosana synteettisiss\u00e4 kannabistuotteissa ja myyty verkossa design-huumeena.<\/p>\n

5F -ADB on vahva CB1-reseptorin agonisti, vaikka sen selektiivisyytt\u00e4 t\u00e4lle reseptorille ei tunneta. 5F-ADB l\u00f6ydettiin ensimm\u00e4isen kerran marraskuussa 2014 k\u00e4ytt\u00e4en post mortem -n\u00e4ytteit\u00e4, jotka oli saatu henkil\u00f6lt\u00e4, joka kuoli t\u00e4t\u00e4 l\u00e4\u00e4kett\u00e4 sis\u00e4lt\u00e4v\u00e4n tuotteen ottamisen j\u00e4lkeen. My\u00f6hemm\u00e4t testit paljastivat, ett\u00e4 5F-ADB:t\u00e4 havaittiin yhteens\u00e4 kymmenell\u00e4 ihmisell\u00e4, jotka kuolivat Japanissa syys-joulukuun 2014 v\u00e4lisen\u00e4 aikana selitt\u00e4m\u00e4tt\u00f6miin huumeiden yliannostuksiin. Kudostesteiss\u00e4 havaittujen suhteellisen alhaisten tasojen perusteella 5F-ADB:n uskotaan olevan poikkeuksellisen vahvaa ja n\u00e4ytt\u00e4\u00e4 olevan huomattavasti vaarallisempi kuin aiemmin myydyt synteettiset kannabisl\u00e4\u00e4kkeet.<\/p>\n

N-[[1-(5-) fluoropentyyli)-1H-indatsol-3-yyli]karbonyyli]<\/p>\n

-3-metyyli-D-valiinimetyyliesteri (5F-ADB) on eritt\u00e4in vahva synteettinen kannabis, joka aiheuttaa ihmisill\u00e4 satunnaisesti vaikeita psykoottisia oireita kohtalokkaasti.<\/p>\n

5F-toksisuuden taustalla olevien hermosolujen mekanismien selvitt\u00e4miseksi ADB:t tutkimme sen vaikutuksia keskiaivojen dopaminergisiin ja serotonergisiin piireihin, jotka s\u00e4\u00e4telev\u00e4t monia aivojen perustoimintoja, mukaan lukien ne, jotka liittyv\u00e4t palkitsemiseen liittyv\u00e4\u00e4n k\u00e4ytt\u00e4ytymiseen. Ex vivo elektrofysiologisia tekniikoita k\u00e4ytettiin rekister\u00f6im\u00e4\u00e4n muutoksia 5F-ADB:n tuottamien dopaminergisten ja serotonergisten hermosolujen spontaanissa laukaisuaktiivisuudessa.<\/p>\n

5F-ADB (1 M) nosti dramaattisesti dopaminergisten hermosolujen spontaanin laukaisunopeutta, mutta ei onnistunut aktivoimaan niit\u00e4 CB1-antagonistin AM251 (1 M) l\u00e4sn\u00e4 ollessa. Toisaalta samalla 5F-ADB:n pitoisuudella ei ollut vaikutusta serotonergiseen hermosolujen aktiivisuuteen. N\u00e4m\u00e4 havainnot osoittavat, ett\u00e4 5F-ADB aktivoi paikallisia CB1-reseptoreita ja tehostaa dopaminergisi\u00e4 j\u00e4rjestelmi\u00e4 keskiaivoissa, mutta sill\u00e4 ei ole vaikutusta keskiaivojen serotonergisiin j\u00e4rjestelmiin.<\/p>\n","protected":false},"excerpt":{"rendered":"

Osta 5F-ADB myyt\u00e4v\u00e4n\u00e4 Isossa-Britanniassa, Euroopassa, Kiinassa (tunnetaan my\u00f6s nimell\u00e4 5F-MDMB-PINACA) on indatsolipohjainen synteettinen kannabinoidi indatsoli-3-karboksamidiperheest\u00e4, tukkutilaus saatavilla<\/p>\n","protected":false},"featured_media":5933,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[2596],"product_tag":[4066,4068,4069,4070,4071,4072,4076,4067,4073,4074,4075],"class_list":{"0":"post-5902","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-kannabinoidit-myynniss","7":"product_tag-5f-adb","8":"product_tag-5f-adb-jauhe","9":"product_tag-5f-mdmb-pinaca","10":"product_tag-buy-5f-adb-online","11":"product_tag-c20h28fn3o3","12":"product_tag-how-to-buy-5f-adb-online","13":"product_tag-mist-ostaa-5f-adb-online","14":"product_tag-5f-adb-myynniss","15":"product_tag-order-5f-adb-online","16":"product_tag-paras-ostopaikka-5f-adb-online","17":"product_tag-v1715016-75-3","19":"first","20":"instock","21":"featured","22":"shipping-taxable","23":"purchasable","24":"product-type-variable"},"yoast_head":"\nOsta 5F-ADB - 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