{"id":5547,"date":"2022-02-22T01:30:48","date_gmt":"2022-02-22T01:30:48","guid":{"rendered":"https:\/\/medicinasinc.com\/ee\/?post_type=product&p=5547"},"modified":"2022-07-05T11:28:02","modified_gmt":"2022-07-05T11:28:02","slug":"osta-jwh-200-keemiline","status":"publish","type":"product","link":"https:\/\/medicinasinc.com\/ee\/product\/osta-jwh-200-keemiline\/","title":{"rendered":"Osta JWH-200 Chemical"},"content":{"rendered":"

K\u00fcsige kemikaali JWH-200 ostmise kohta<\/p>\n

Nafto\u00fc\u00fclindoolide perekonnas on AM-678 (1-pent\u00fc\u00fcl-3-(1-nafto\u00fc\u00fcl)indool) valuvaigisti, mis on t\u00e4ielik agonist nii CB1 kui ka CB2 kannabinoidi retseptorid, eelistades veidi CB2 retseptorit. Seda kasutatakse s\u00fcnteetilistes kanepitoodetes, mida m\u00f5nes riigis m\u00fc\u00fcakse legaalselt “viiruksegudena”, kuna selle m\u00f5ju loomadele on v\u00f5rreldav kanepis looduslikult leiduva kannabinoidi tetrah\u00fcdrokannabinooli (THC) toimega. Uurimiskemikaalid JWH-200<\/p>\n

Kasutades Wistari rotte, kellele oli antud JWH-200 sisaldavat etanooliekstrakti, uuriti ravimi metaboolset aktiivsust. Sellele j\u00e4rgnes JWH-200 metaboliitide ekstraheerimine 24-tunnistest uriiniproovidest, kasutades nii vedelat kui ka tahket eraldamise faasi. Ekstraheeritud kemikaalid eraldati ja identifitseeriti GC-MS abil. Peamine signaal oli h\u00fcdroks\u00fc\u00fclitud N-dealk\u00fc\u00fclitud metaboliidid, mitte JWH-200 v\u00f5i selle N-dealk\u00fc\u00fclitud metaboliit. T\u00e4heldatud massinihe viitab sellele, et molekuli naftaleeni ja indooli h\u00fcdroks\u00fc\u00fclr\u00fchmad l\u00e4bivad t\u00f5en\u00e4oliselt h\u00fcdroks\u00fc\u00fclimise. H\u00fcdroks\u00fc\u00fclitud metaboliidid konjugeeriti inimestel laialdaselt gl\u00fckuroniidiga, kuigi indoolits\u00fckkel ja pent\u00fc\u00fclk\u00fclgahel olid peamised metabolismi kohad.<\/p>\n

JWH-200 keemiline kasutamine teadusuuringutes<\/p>\n

Meedia on teatas v\u00e4hemalt \u00fchest JWH-200 s\u00f5ltuvuse juhtumist. Kaheksa kuu jooksul j\u00f5i kasutaja JWH-018 igap\u00e4evaselt. V\u00f5rreldes kanepis\u00f5ltuvuse m\u00f5judega olid v\u00f5\u00f5rutusn\u00e4hud siin tugevamad. P\u00e4rast ravi on n\u00e4idatud, et JWH-200 p\u00f5hjustab olulisi muutusi CB1 retseptori tiheduses. V\u00e4hem kiiresti kui v\u00f5rreldavad kannabinoidid, p\u00f5hjustab see tolerantsust selle toime suhtes.<\/p>\n","protected":false},"excerpt":{"rendered":"

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Ostke JWH-200 keemiline pulber\u00a0 \u00dchendkuningriigis ja Euroopas Internetis m\u00fc\u00fcgiks. (1-(2-morfoliin-4-\u00fc\u00fclet\u00fc\u00fcl)indool-3-\u00fc\u00fcl)naftaleen-1-\u00fc\u00fclmetanoon on teine \u200b\u200bnimi. Tule ja osta kohe!. Meil on parim diskreetne pakkimis- ja saatmisviis.<\/p>\n<\/p><\/div>\n","protected":false},"featured_media":5556,"comment_status":"open","ping_status":"closed","template":"","meta":{"_members_access_role":[],"_members_access_error":""},"product_brand":[],"product_cat":[2014],"product_tag":[3029,3033,3034,3035,3037,3038,3046,3042,3044,3040,3036,3041,3045,3043,3047,3049,3039,3030,3031,3032,3048],"class_list":["post-5547","product","type-product","status-publish","has-post-thumbnail","product_cat-ostke-uurimiskemikaale","product_tag-am-2233","product_tag-how-to-order-jwh-200-online","product_tag-jwh-018","product_tag-jwh-073","product_tag-jwh-200-efekt","product_tag-jwh-200-efektid","product_tag-jwh-200-hulgimk","product_tag-jwh-200-jaemk","product_tag-jwh-200-mk","product_tag-jwh-200-order","product_tag-jwh-200-osta","product_tag-jwh-200-reddit","product_tag-jwh-200-sell","product_tag-jwh-200-levaade","product_tag-jwh-250","product_tag-kust-tellida-jwh-200-uuringute-kemikaalid","product_tag-jwh-200-mgiks","product_tag-osta-jwh-200-keemiline","product_tag-osta-jwh-200-veebis","product_tag-osta-jwh-200-research-chemicals","product_tag-osta-jwh-200-uurimus-kemikaalid","first","instock","shipping-taxable","purchasable","product-type-variable","has-default-attributes"],"yoast_head":"\nOsta JWH-200 Chemical \u2013 JWH-200 Chemical \u2013 parimad \u00fclemaailmsed ravimid<\/title>\n<meta name=\"description\" content=\"Ostke \u00dchendkuningriigis ja Euroopas Internetis m\u00fc\u00fcgiks JWH-200 keemiline pulber. 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