{"id":5902,"date":"2022-02-22T08:09:55","date_gmt":"2022-02-22T08:09:55","guid":{"rendered":"https:\/\/medicinasinc.com\/da\/?post_type=product&p=5902"},"modified":"2022-03-19T21:06:00","modified_gmt":"2022-03-19T21:06:00","slug":"kob-5f-adb","status":"publish","type":"product","link":"https:\/\/medicinasinc.com\/da\/product\/kob-5f-adb\/","title":{"rendered":"K\u00f8b 5F-ADB"},"content":{"rendered":"

5F-ADB (alternativt stavet 5F-MDMB-PINACA) er et syntetisk cannabinoid afledt af indazol, der er blevet brugt som en aktiv ingrediens i syntetiske cannabisprodukter og solgt online som et designerl\u00e6gemiddel.<\/p>\n

5F -ADB er en st\u00e6rk agonist af CB1-receptoren, omend dens selektivitet for denne receptor er ukendt. 5F-ADB blev fundet for f\u00f8rste gang i november 2014 ved hj\u00e6lp af obduktionspr\u00f8ver erhvervet fra en person, der d\u00f8de efter at have taget et produkt indeholdende dette l\u00e6gemiddel. Efterf\u00f8lgende test viste, at 5F-ADB blev p\u00e5vist hos i alt ti mennesker, der d\u00f8de i Japan mellem september og december 2014 af uforklarlige overdoser af medicin. Baseret p\u00e5 de relativt lave niveauer, der er opdaget i v\u00e6vstest, menes 5F-ADB at v\u00e6re ekstraordin\u00e6rt st\u00e6rk og ser ud til at v\u00e6re v\u00e6sentligt mere farlig end tidligere solgt syntetisk cannabismedicin.<\/p>\n

N-[[1-(5- fluorpentyl)-1H-indazol-3-yl]carbonyl]<\/p>\n

-3-methyl-D-valin methylester (5F-ADB) er en meget st\u00e6rk syntetisk cannabis, der for\u00e5rsager alvorlige psykotiske symptomer hos mennesker, lejlighedsvis fatalt.<\/p>\n

For at belyse de neuronale mekanismer bag 5F-toksicitet har ADB’er unders\u00f8gt dets virkninger p\u00e5 mellemhjernens dopaminerge og serotonerge kredsl\u00f8b, som regulerer en r\u00e6kke fundamentale hjernefunktioner, inklusive dem, der er forbundet med bel\u00f8nningsrelateret adf\u00e6rd. Ex vivo elektrofysiologiske teknikker blev brugt til at registrere \u00e6ndringer i den spontane affyringsaktivitet af dopaminerge og serotonerge neuroner produceret af 5F-ADB.<\/p>\n

5F-ADB (1 M) \u00f8gede dramatisk den spontane affyringshastighed af dopaminerge neuroner, men undlod at aktivere dem i n\u00e6rv\u00e6relse af CB1-antagonisten AM251 (1 M). Den samme koncentration af 5F-ADB havde p\u00e5 den anden side ingen effekt p\u00e5 serotonerge neuronaktivitet. Disse resultater viser, at 5F-ADB aktiverer lokale CB1-receptorer og forbedrer dopaminerge systemer i mellemhjernen, mens det ikke har nogen effekt p\u00e5 serotonerge systemer i mellemhjernen.<\/p>\n","protected":false},"excerpt":{"rendered":"

K\u00f8b 5F-ADB til salg Storbritannien, Europa, Kina (ogs\u00e5 kendt som 5F-MDMB-PINACA) er en indazol-baseret syntetisk cannabinoid fra indazol-3-carboxamid-familien, tilg\u00e6ngelig engrosordre<\/p>\n","protected":false},"featured_media":5933,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[2596],"product_tag":[4066,4068,4067,4069,4073,4070,4071,4074,4076,4072,4075],"class_list":{"0":"post-5902","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-cannabinoider-til-salg","7":"product_tag-5f-adb","8":"product_tag-5f-adb-pulver","9":"product_tag-5f-adb-til-salg","10":"product_tag-5f-mdmb-pinaca","11":"product_tag-bestil-5f-adb-online","12":"product_tag-buy-5f-adb-online","13":"product_tag-c20h28fn3o3","14":"product_tag-det-bedste-at-kbe-5f-adb-online","15":"product_tag-hvor-kan-kbes-5f-adb-online","16":"product_tag-sdan-kber-man-5f-adb-online","17":"product_tag-v1715016-75-3","19":"first","20":"instock","21":"featured","22":"shipping-taxable","23":"purchasable","24":"product-type-variable"},"yoast_head":"\nK\u00f8b 5F-ADB - 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